Digestive and Metabolic Diseases

Peptic Ulcer and Acid-related Disorders

Peptic ulcer disease and other acid-related disorders like gastroesophageal reflux disease (GERD) affect millions worldwide, leading to significant morbidity and healthcare costs. These conditions arise from the imbalance between gastric acid secretion and mucosal protection. Helicobacter pylori infection and non-steroidal anti-inflammatory drugs (NSAIDs) are primary causes of peptic ulcers, while lifestyle factors often contribute to GERD.

This session examines the pathogenesis, diagnosis, and management of peptic ulcers and GERD. Topics include advancements in acid suppression therapy, the role of endoscopy in diagnosis, eradication therapies for Helicobacter pylori, and emerging concerns such as treatment-resistant strains. Long-term complications like Barrett’s esophagus and ulcer perforation will also be addressed.

Key Topics:

• Pathophysiology of acid-related disorders

• Helicobacter pylori infection and treatment

• GERD: diagnosis and lifestyle management

• Proton pump inhibitors and new therapies

• Endoscopy in ulcer evaluation

• Complications: bleeding and perforation

• Drug-resistant H. pylori strains

• Barrett’s esophagus and cancer risk

• NSAID-induced ulcers

• Non-pharmacologic treatment strategies